Eye-Preservation Treatment of Retinoblastoma with Vitreous Seeding
نویسندگان
چکیده
منابع مشابه
Intravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.
OBJECTIVE To evaluate the efficacy and complications of intravitreal chemotherapy for viable vitreous seeding from retinoblastoma. METHODS Intravitreal injection of melphalan (8-50 μg in 0.05 mL) followed by injection site cryotherapy. RESULTS Among 12 treated cases, success with control of vitreous seeds was achieved in 10 of 12 cases at immediate follow-up (0-3 months), 8 of 10 cases at s...
متن کاملIntravitreal Chemotherapy for Vitreous Seeding Caused by Retinoblastoma
Vitreous seeding is one of the primary reasons for treatment failure following conservative management of retinoblastoma.1,2 In our hands, until early 2006, most children with recurrent vitreous seeding were managed with plaque radiotherapy, external beam radiotherapy, or enucleation.1,2 In 2006, following the initial experience of Kaneko and Suzuki in Japan,3 we performed the first intravitrea...
متن کاملAssociated with Vitreous Seeding of Retinoblastoma Allelic Loss in a Minimal Region on Chromosome 16q24 Is
In addition to RB1 gene mutations, retinoblastomas frequently show gains of 1q and 6p and losses of 16q. To identify suppressor genes on 16q, we analyzed 22 short tandem repeat loci in 58 patients with known RB1 mutations. A subset of tumors was also investigated by conventional and matrix comparative genomic hybridization. In 40 of 58 (69%) tumors, we found no loss of heterozygosity (LOH) at a...
متن کاملAllelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma.
In addition to RB1 gene mutations, retinoblastomas frequently show gains of 1q and 6p and losses of 16q. To identify suppressor genes on 16q, we analyzed 22 short tandem repeat loci in 58 patients with known RB1 mutations. A subset of tumors was also investigated by conventional and matrix comparative genomic hybridization. In 40 of 58 (69%) tumors, we found no loss of heterozygosity (LOH) at a...
متن کاملIntra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results.
BACKGROUND/AIMS To review the effectiveness of intra-arterial chemotherapy for advanced intra-ocular retinoblastoma with vitreous and/or subretinal seeds in naive (untreated) and previously treated eyes. METHODS Retrospective study, approved by the institutional review board, of 76 eyes of 67 patients with retinoblastoma with subretinal and/or vitreous seeding treated with intra-arterial chem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 2003
ISSN: 1465-3621
DOI: 10.1093/jjco/hyg113